Influence of the peptide chain length of new elongated tuftsin analogs on phagocytosis process |
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| Authors: | DANUTA KONOPI&#x SKA,BERNADA KAZANOWSKA,JANINA BOGUS?WSKA-JAWORSKA |
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| Affiliation: | DANUTA KONOPIŃSKA,BERNADA KAZANOWSKA,JANINA BOGUS?WSKA-JAWORSKA |
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| Abstract: | In this paper the synthesis of the following elongated tuftsin analogs: Arg-Thr-Lys-Pro-Arg (1), Pro-Arg-Thr-Lys-Pro-Arg(II), Lys-Pro-Arg-Thr-Lys-Pro-Arg(III) and Thr-Lys-Pro-Arg-Thr-Lys-Pro-Arg(IV) by classical and solid-phase methods are described. The obtained peptides were tested for their biological activity: restoration of the phagocytosis of defected granulocytes from blood of children with acute lymphoblastic leukemia (ALL). |
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| Keywords: | phagocytosis stimulating factor tuftsin tuftsin analogs. |
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