| Abstract: | How drug concentration in skin and lung due to vascular action changed with aging was examined quantitatively by a bioassay using bacteria. The concentration of the drug (anticancerous agent, Bleomycin) did not decrease in the skin of older mice as compared with that in younger mice, but showed a decrease in the lungs. An experiment using Kallikrein, a peripheral vasodilator, revealed that the kinin-kallikrein system exists in mice. The peripheral circulation increasing action of Kallikrein decreased in the skin and increased in the lungs of older mice as compared with young mice. |
