| Abstract: | The effects of mouse and human epidermal growth factors (mEGF and hEGF) on the outgrowing epidermis of pig and human skin explants were studied. Both mEGF and hEGF significantly stimulated the rate of pig and human epidermal outgrowth at 0.01–0.05 µg/ml. mEGF also stimulated mitosis of pig outgrowing epidermis. The stimulatory effect of mEGF on the rate of pig epidermal outgrowth and mitosis of pig outgrowing epidermis was potentiated by fetal calf serum. These results indicate that EGF may have a possibile clinical application in epidermal wound healing. |
