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| 醒脑静注射液对脑缺血-再灌注损伤家兔血清白介素-8的影响 | |
| 引用本文： | 王万铁,陈寿权,徐正祄,王卫,李惠萍,黄唯佳,程俊彦,赵初环,方周溪,卢中秋.醒脑静注射液对脑缺血-再灌注损伤家兔血清白介素-8的影响[J].温州医学院学报,2003,33(1):1-3. |
| 作者姓名： | 王万铁 陈寿权 徐正祄 王卫 李惠萍 黄唯佳 程俊彦 赵初环 方周溪 卢中秋 |
| 作者单位： | 1. 温州医学院,病理生理教研室,浙江,温州,325027 2. 温州医学院第一附属医院,浙江,温州,325000 3. 温州医学院,电镜室,浙江,温州,325027 |
| 基金项目： | 浙江省中医药科研基金资助项目 (980 37) |
| 摘 要： | 目的 :观察醒脑静注射液 (XNJI)对脑缺血 再灌注损伤 (CIRI)家兔血清白介素 8(IL 8)水平的影响 ,并探讨其脑保护机制。方法 :2 8只家兔随机分为假手术对照组 (C组 )、缺血再灌注组 (I R组 )和醒脑静注射液组 (XNJI组 ) ,分别在缺血前、缺血 3 0min、再灌注 3 0min、60min、12 0min时取静脉血 ,测定血清IL 8浓度 ,实验结束后取脑组织观察脑超微结构的变化。结果 :脑缺血 再灌注期间 ,I R组不同时点血清IL 8水平明显高于XNJI组 ,缺血 3 0min为 (0 .62± 0 .18)ng·L-1及 (0 .43± 0 .0 8)ng·L-1,P <0 .0 5 ;再灌注 3 0min ,为血清IL 8水平 (0 .73± 0 .19)ng·L-1及 (0 .45± 0 .0 9)ng·L-1;再灌注 60min ,血清IL 8水平为 (0 .87± 0 .2 9)ng·L-1及 (0 .47± 0 .0 6)ng·L-1;再灌注 12 0min血清IL 8水平为 (1.0 3± 0 .43 )ng·L-1及 (0 .44± 0 .0 7)ng·L-1,再灌注各时点组均P <0 .0 1,超微结构发生异常改变 ;XNJI组不同时点血清IL 8浓度显著低于I R组 (XNJI组缺血 3 0min为(0 .48± 0 .0 7)ng·L-1,P <0 .0 5 ;再灌注 3 0min为 (0 .5 0± 0 .0 8)ng·L-1;再灌注 60min为 (0 .5 5± 0 .14)ng·L-1;再灌注 12 0min为 (0 .5 9± 0 .17)ng·L-1,再灌注各时点组P <0 .0 1) ,其超微结构异常改变较I R组 |
| 关 键 词： | 醒脑静注射液 脑缺血－再灌注损伤 白细胞介素—8 |
| 文章编号： | 1000-2138(2003)01-001-03 |
| 修稿时间： | 2002年1月7日 |
Effect of Xingnaojing injection on serum interleukin-8 in rabbits following cerebral ischemia-reperfusion injury |
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| WANG Wan tie ,CHEN Shou quan,XU Zheng jie,et al..Effect of Xingnaojing injection on serum interleukin-8 in rabbits following cerebral ischemia-reperfusion injury[J].Journal of Wenzhou Medical College,2003,33(1):1-3. | |
| Authors: | WANG Wan tie CHEN Shou quan XU Zheng jie |
| Institution: | WANG Wan tie *,CHEN Shou quan,XU Zheng jie,et al. * Department of Pathophysiology,Wenzhou Medical College,Wenzhou 325027 |
| Abstract: | Objective:To determine the inhibitory effect of xingnaojing injection(XNJI) on the level of serum interleukin 8(IL 8) following cerebral ischemia and reperfusion injury(CIRI) in rabbits.Methods:28 rabbits were randomly divided into three groups:control group(group C),ischemia reperfusion group(group I R)and XNJI group(group XNJI). Blood samples were obtained through vein,to measure the serum concentration of IL 8 25 min before ischemia,ischemia 30 min,30 min,60 min and 120 min after reperfusion. The ultrastructure changes of the cerebral tissue were observed.Results:Serum IL 8 levels at different time point in group I R were significantly higher than those of the group C(P<0.05 and P<0.01). The abnormal morphological changes of cerebral cells under electron microscope were more obvious in the group I R. Serum IL 8 levels at different time point in the group XNJI were remarkably lower than those of the group I R(P<0.05 and P<0.01);the abnormal morphyological changes of cerebral cells were all alleviated markedly after treatment of XNJI.Conclusion:XNJI can effectively decrease serum IL 8,protect the brain from ischemia and reperfusion injury. |
| Keywords: | xingnaojing injection cerebral ischemia reperfusion injury interleukin 8 |
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