| 不明原因肝功能异常患者自身抗体的检测及对自身免疫性肝病的临床意义 |
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| 引用本文： | 陈瀑,严立,叶荻庆,祝继华,张莉萍.不明原因肝功能异常患者自身抗体的检测及对自身免疫性肝病的临床意义[J].重庆医学,2011,40(3):239-241. |
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| 作者姓名： | 陈瀑 严立 叶荻庆 祝继华 张莉萍 |
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| 作者单位： | 重庆医科大学附属第一医院检验科,400016 |
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| 摘 要： | 目的研究自身免疫性肝病的诊疗现状,以提高对该类疾病的认识和诊断水平。方法对2007~2010年临床初诊为不明原因肝功能异常的186例患者的主要实验室特征进行回顾性分析。结果 186例患者中自身抗体总阳性率为31.7%,其中抗核抗体(ANA)阳性42例(22.6%),抗线粒体抗体(AMA)阳性14例(7.5%),抗平滑肌抗体(SMA)阳性5例(2.7%),抗肝肾微粒体抗体(LKM)阳性0例;自身免疫性肝炎和原发性胆汁性肝硬化检出率分别为9.7%和7.5%;自身免疫性肝炎患者检出阳性率最高的自身抗体为ANA,原发性胆汁性肝硬化患者主要出现AMA抗体;95%自身免疫性肝病患者自身抗体滴度大于或等于1∶320;原发性胆汁性肝硬化患者碱性磷酸酶(ALP)和γ-谷氨酰转移酶(GGT)较自身免疫性肝炎患者显著升高(P<0.05)。结论高滴度的自身抗体对自身免疫性肝病有诊断价值,分析肝功能指标、免疫球蛋白、血清蛋白电泳等实验室数据也有助于自身免疫性肝病的诊断。
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| 关 键 词： | 肝炎 自身免疫性 肝硬化 胆汁性 自身抗体 |
The detection of autoantibody and autoimmune liver disease in patients with abnormal liver function of unknown etiology |
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| Chen Pu,Yan Li,Ye Diqing,Zhu Jihua,Zhang Liping.The detection of autoantibody and autoimmune liver disease in patients with abnormal liver function of unknown etiology[J].Chongqing Medical Journal,2011,40(3):239-241. |
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| Authors: | Chen Pu Yan Li Ye Diqing Zhu Jihua Zhang Liping |
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| Institution: | Chen Pu,Yan Li,Ye Diqing,Zhu Jihua,Zhang Liping(Department of Laboratory,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China) |
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| Abstract: | Objective To study autoimmune liver disease clinics status quo in order to raise awareness of the disease and the diagnosis level.Methods 186 cases of patients with abnormal liver function of unknown etiology in our hospital from 2007 to 2010 were studied retrospectively according to the main features of laboratory analysis.Results Among the 186 cases,31.7% of them showed autoantibody positive with 42 cases ANA positive(22.6%),14 cases AMA positive(7.4%),5 cases SMA positive(2.7%),0 case LKM positive.The po... |
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| Keywords: | hepatitis autoimmune liver cirrhosis biliary autoantibodies |
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