氟哌噻吨美利曲辛治疗胃溃疡伴抑郁症的临床研究

目的观察在常规治疗的基础上加用氟哌噻吨美利曲辛治疗胃溃疡伴抑郁症的疗效。方法对经胃镜确诊为胃溃疡的患者采用Hamiltion抑郁量表(HAMD)进行评分,总分大于或等于20分及以上者共78例,分为常规治疗组及常规治疗加用氟哌噻吨美利曲辛组,8周后复查胃镜,观察其疗效。结果两组均有效;但常规治疗加用氟哌噻吨美利曲辛组治愈率明显高于常规治疗组(P<0.05),且无明显不良反应。结论对于伴抑郁症的胃溃疡患者在常规治疗基础上加用氟哌噻吨美利曲辛治疗效果更好,不良反应小,安全有效。

Clinical research on treatment of stomach ulcer accompanied with depression by Flupentixol and Melitracen tablets

Objective To observe the efficacy and side effects of Flupentixol and Melitracen tablets in treatment of stomach ulcer accompanied with depression.Methods Hamiltion Depression Scale(HAMD) score was used to evaluate 121 stomach ulcer patients with suspicious depression;among them 78 patients whose scores were ≥20 points received deanxit or doxepin for a eight-week therapeutic period.After the treatment,the therapeutic effects of the two groups were observed,compared and reevaluated with the HAMD scale.Results The therapeutic effects of the two groups were both significant(P<0.05).The efficacy between these two groups showed statistically significant difference(P<0.05);while there were little side effects in Flupentixol and Melitracen tablets group.Conclusion Flupentixol and Melitracen tablets is effective,safe and takes into effect fast with fewer side effects for the treatment of stomach ulcer accompanied with depression.