| Caveolin-1蛋白及mRNA在食管鳞状细胞癌组织中的表达 |
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| 引用本文： | 楚广民,庞霞,高冬玲.Caveolin-1蛋白及mRNA在食管鳞状细胞癌组织中的表达[J].重庆医学,2011,40(4). |
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| 作者姓名： | 楚广民 庞霞 高冬玲 |
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| 作者单位： | 楚广民,Chu Guangmin(河南省肿瘤医院病理科,郑州,450008);庞霞,高冬玲,Pang Xia,Gao Dongling(郑州大学第一附属医院病理科/河南省肿瘤病理重点实验室,450052) |
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| 摘 要： | 目的 探讨窖蛋白1(Caveolin-1)蛋白及mRNA在食管鳞状细胞癌(ESCC)组织中的表达及其意义.方法 应用免疫组织化学及原位杂交方法检测57例ESCC组织、34例癌旁不典型增生组织及57例正常食管黏膜组织中Caveolin-1蛋白及mRNA的表达.结果 ESCC组织、癌旁不典型增生组织及正常黏膜组织中Caveolin-1蛋白的阳性表达率依次降低,分别为54.4%(31/57)、38.2%(13/34)和19.3%(11/57),组间比较差异均有统计学意义(P<0.05);ESCC组织、癌旁不典型增生组织及正常黏膜组织中Caveolin-1 mRNA的阳性表达率依次降低,分别为64.9%(37/57)、47.1%(16/34)和22.8%(13/57),组间比较差异均有统计学意义(P<0.05);Caveolin-1蛋白及mRNA的表达均与ESCC的分化程度、浸润深度和淋巴结转移密切相关(P<0.05).结论 Caveolin-1蛋白及mRNA表达与ESCC的发生、发展和转移密切相关,可作为ESCC的一种标记物,联合检测Caveolin-1蛋白及mRNA在评估ESCC预后方面具有一定的临床价值.
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| 关 键 词： | 窖蛋白1 肿瘤 鳞状细胞 免疫组织化学 原位杂交 |
Expression of Caveolin-1 protein and mRNA in esophageal squamous cell carcinoma tissue |
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| Chu Guangmin,Pang Xia,Gao Dongling.Expression of Caveolin-1 protein and mRNA in esophageal squamous cell carcinoma tissue[J].Chongqing Medical Journal,2011,40(4). |
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| Authors: | Chu Guangmin Pang Xia Gao Dongling |
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| Institution: | Chu Guangmin1,Pang Xia2,Gao Dongling2(1.Department of Pathology,Henan Province Tumor Hospital,Zhengzhou,Henan 450008,China,2.Department of Pathology,Henan Key Laboratory of Tumor Pathology/the First Affiliated Hospital,Zhengzhou University,Henan 450052,China) |
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| Abstract: | Objective To investigate the expressions of Caveolin-1 protein and mRNA in esophageal squamous cell carcinoma(ESCC)tissues and its significance.Methods The expressions of Caveolin-1 protein and mRNA was detected by immunohistoche-mistry and in situ hybridization methods in 57 cases of ESCC tissues,34 cases of adjacent atypical hyperplasia epithelial tissues and 57 cases of normal esophageal epithelial tissues.Results The positive expression rate of Caveolin-1 protein gradually decreased from 54.4%(31/57)in ... |
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| Keywords: | Caveolin-1 carcinoma squamous cell immunohistochemistry in situ hybridization |
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