Neuroprotective effect of afobazole on rats with bilateral local photothrombosis of vessels in the prefrontal cortex |
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| Authors: | S. B. Seredenin G. A. Romanova F. M. Shakova |
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| Affiliation: | (1) V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia;(2) Institute of General Pathology and Pathophysiology, Moscow, Russia |
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| Abstract: | We studied the neuroprotective effect of a new selective anxiolytic afobazole on rats with bilateral focal ischemic stroke in the prefrontal cortex caused by photothrombosis. Intraperitoneal injection of 5 mg/kg afobazole 1 h after surgery and over the next 8 days (daily treatment) produced a neuroprotective effect. Afobazole was far superior to the reference cerebroprotective drug cavinton (4 mg/kg) by neuroprotective activity. __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 2, pp. 167–169, February, 2008 |
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| Keywords: | afobazole cavinton neuroprotection photothrombosis of the prefrontal cortex |
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