肝动脉化疗栓塞及注射32P-胶体、无水乙醇综合序贯介入治疗原发性肝癌疗效分析

目的　评价肝动脉化疗栓塞（ＴＡＣＥ） 及Ｂ 超引导下注射３２Ｐ胶体、无水乙醇（ＰＥＩ） 综合序贯介入治疗原发性肝癌的临床价值。方法　５１ 例中晚期肝癌分为２ 组，２３ 例综合序贯应用ＴＡＣＥ＋ ３２Ｐ＋ ＰＥＩ治疗，２８ 例单纯应用ＴＡＣＥ 治疗。结果　综合序贯组肿瘤缩小率、肿瘤完全坏死率、ＡＦＰ下降率分别为９１ ．２９ ％ 、８０ ．００ ％ 、８７ ．５ ％ ，而单纯ＴＡＣＥ组分别为３９．２７％ 、３０ ．４３％ 、４１ ．４６ ％ ，两组比较有显著性差异（ Ｐ＜０ ．０１），６ 个月、１、２ 、３ 年生存率综合序贯组分别为９５．６５ ％ 、８６．９５％ 、５６ ．５２ ％ 、２０．７３ ％ ，而单纯ＴＡＣＥ 组分别为６４．２８％ 、３９．２８ ％ 、１７ ．８５ ％ 、００ ．００ ％ （Ｐ＜ ０．０１） 。结论　ＴＡＣＥ＋ ３２Ｐ＋ ＰＥＩ的综合序贯介入治疗是提高中晚期原发性肝癌患者生存率的有效方法。

Therapeutic effect of combination and sequencial interventional treatment on primary liver cancer with transcatheter arterial chemoembolization combined with radioactive colloidal phosephate and percutaneous ethanol injection under ultrasound guidance

Objective To evaluate the clinical efficacy of transcatheter arterial chemoembolization (TACE) combined with radioactive colloidel phosephate ( 32 P) and percutaneous ethanol injection (PEI) in the treatment of primary liver cancer (PLC). Methods 51 cases of moderate and advanced stages of PLC were divided into two groups, 23 cases were treated with TACE and followed subsequently by 32 P and PEI (group A). 28 cases were treated with TACE alone (group B). Results The rates of reduction in tumor diameter and tumor complete necrosis and the decline in serum AFP level in group A were 91.29%, 80.00% and 87.5%, while those of group B were 39.27%, 30.43% and 41.46% respectively. There was significant difference between the two groups ( P <0.01). The 6 month, 1-,2-,3-year survival rates of group A were 95.65%, 86.95%, 56.52%, 20.73%, respectively; in contrast, those of group B were 64.28%, 39.28%, 17.85%, 00.00%,respectively ( P <0.01). Conclusions The combination and sequencial interventional treatment on PLC with TACE combined with 32 P and PEI is an efficient method for increasing the survival rate.