Comparative study of Astemizole—A new H1 antagonist with a conventional antihistaminic in patients with allergic rhinitis

A double blind study to evaluate in allergic rhinitis the efficacy of Astemizole with a classical antihistaminic—Chlorpheneramine is described. The results indicate that there is a significantly better clinical improvement with Astemizole compared with Chlorpheneramine. Except of weight gain, adverse Cholinergic and sedative effects were also minimal with Astemizole.