丙泊酚复合不同浓度利多卡因预防注射痛的临床研究

目的研究丙泊酚注射液内添加不同浓度利多卡因对丙泊酚注射痛的预防作用。方法择期手术患者250例,ASAⅠ～Ⅲ级,随机均分为五组,A组为单纯丙泊酚组,B组为丙泊酚注射液中含利多卡因0.5mg/ml,C组丙泊酚内含利多卡因1mg/ml,D组丙泊酚内含利多卡因2mg/ml,E组为利多卡因预处理组,在注射丙泊酚前给予利多卡因40mg。记录患者静注丙泊酚过程中的疼痛情况。结果 A组注射痛发生率显著高于其它四组(P<0.01)。D组未发生丙泊酚注射痛。结论在丙泊酚注射液内添加利多卡因能有效地抑制或减轻丙泊酚注射痛,内含利多卡因2mg/ml能够完全抑制注射痛,利多卡因对丙泊酚的麻醉作用没有影响。

The prophylactic effect of lidocaine in different concentrations on propofoi-induced injection pain

Objective To study the prophylactic effect of lidocaine in different concentrations added to propofol on the propofol-induced injection pain.Methods A total of 250 ASA Ⅰ-Ⅲ patients scheduled to undergo elective surgery,were randomly assigned into five groups(n=50 each).Group A received propofol without lidocaine;group B received propofol with lidocaine 0.5 mg/ml;group C received propofol with lidocaine 1 mg/ml;group D received propofol with lidocaine 2 mg/ml;group E was pretreated with lidocaine 40 mg intravenously before propofol injection.The severity of pain when injecting propofol was assessed and recorded.Results The incidence of propofol injection pain in group A was significantly higherthan those in the other groups(P<0.01).Propofol injection pain was not observed in group D.Conclusion Lidocaine added to propofol injection can effectively suppress or attenuate the propofol-induced injection pain and lidocaine 2 mg/ml can completely block the pain without affecting propofol anesthesia.