p21Waf1/Cip1与Skp2在涎腺肿瘤中的表达及意义

目的:研究p21 Waf1/Cip1与Skp2在涎腺良、恶性肿瘤中的表达及临床意义。方法:应用免疫组织化学SABC法检测10例正常涎腺组织、20例涎腺良性肿瘤、33例涎腺恶性肿瘤组织中p21 Waf1/Cip1和Skp2蛋白的表达情况,分析它们表达之间的相关性。结果:p21 Waf1/Cip1在涎腺正常组织以及涎腺良、恶性肿瘤的表达率依次降低,各组之间存在显著性差异(x2=11.113,P=0.006)。Skp2在涎腺恶性肿瘤中的阳性表达率(75.76%)明显高于良性肿瘤组织(35.00%),差异有显著性意义(x2=19.128,P=0.001)。p21 Waf1/Cip1与Skp2在涎腺良性肿瘤中的表达呈负相关,但相关性不明显(r=-0.390,P=0.089);它们在涎腺恶性肿瘤中的表达呈显著性负相关(r=-0.467,P=0.006)。结论:p21Waf1/Cip1低表达以及Skp2高表达与涎腺肿瘤的发生、发展密切相关。Skp2可能通过下调p21 Waf1/Cip1蛋白的表达而参与涎腺肿瘤的形成过程。

Expression of p21Wafl / Cipl and Skp2 in salivary gland tumors and their significance.

Objective： To investigate the expression and clinical significance of p21 Wall / Cipl and Skp2 in salivary gland tumors. Method： The expression of p21 Wafl / Cipl and Skp2 in 10 cases of normal salivary gland tissues, 20 cases of benign salivary gland tumor tissues and 33 cases of malignant salivary gland tumor tissues were detected by immunohisto- chemical SABC method,analyzing the correlations between their expression to each other. Result：The expression rates of p21 Wafl / Cipl in normal salivary gland, benign salivary gland tumor and malignant salivary gland tumor tissues decreased gradually, and the differences were significant （x2=1 1.113, P =0.006）. The positive rate of Skp2 in the malignant salivary gland tumors （75.76 %） was significantly higher than that in the benign salivary gland tumors （35.00 %） （x2=19.128,P = 0.001）. There was a inverse correlation between the expression of p21 Wafl / Cipland Skp2 in the benign salivary gland tu- mors, but the correlation was not significant @=-0.390, P =0.089）. There was a significantly inverse correlation between their expression in the malignant salivary gland tumors （r=-0.467, P =0.006）. Conclusion： The low expression of p21 Wafl / Cipl and overexpression of Skp2 was highly associated With the occurrence and development of salivary gland tumors.Skp2 may take part in the development of salivary gland tumors through downregnlaiting the expression of p21 Waft / Cipl.