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| 一种新型冻干骨材料的安全性初步评价 | |
| 引用本文： | 赵彦涛,侯树勋,闫钧,霍娜,衷鸿宾,周颖. 一种新型冻干骨材料的安全性初步评价[J]. 临床口腔医学杂志, 2012, 28(8): 454-456 |
| 作者姓名： | 赵彦涛 侯树勋 闫钧 霍娜 衷鸿宾 周颖 |
| 作者单位： | 1. 解放军总医院第一附属医院·全军骨科研究所 北京 100048 2. 第四军医大学口腔医学院修复科 西安陕西710032 3. 解放军总医院口腔医学中心 北京 100853 |
| 基金项目： | 国家自然科学基金青年项目:NSFC 81000417解放军总医院苗圃基金:10KMM33，解放军总医院临床部课题:QN201104 |
| 摘 要： | 目的:对一种新型掺锶冻干骨材料的安全性进行评价。方法:用离子交换方法制备掺锶冻干骨材料,制备浸提液,选择L929细胞通过MTT方法进行细胞毒性检验;应用小鼠进行体内植入,观察材料的异常毒性。结果:本实验制备的掺锶冻干骨材料锶元素含量为5.14%,细胞毒性评级为安全无毒级,小鼠体内实验未见异常毒性。结论:新型掺锶冻干骨材料是一种较为安全的新型骨替代材料。 |
| 关 键 词： | 同种骨 冻干骨 锶元素 生物安全性 |
Primary safety evaluation of a novel freeze dried bone |
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| ZHAO Yan-tao , HOU Shu-xun , YAN Jun , HUO Na , ZHONG Hong-bin , ZHOU Ying. Primary safety evaluation of a novel freeze dried bone[J]. Journal of Clinical Stomatology, 2012, 28(8): 454-456 | |
| Authors: | ZHAO Yan-tao HOU Shu-xun YAN Jun HUO Na ZHONG Hong-bin ZHOU Ying |
| Affiliation: | 1.Institute of Orthopedics, The First Affiliated Hospital of the General Hospital of People＇s Liberation Army, Beijing 100048, China; 2.Department of Prosthodontic , the Fourth Military Medical University, Shartxi X i ＇an 710032, China.. 3.Center of Stomatology , the General Hospital of People ＇s liberation Army, Beijing 100853, China. |
| Abstract: | Objective：To evaluate the safety of a novel Sr-incorporated freeze dried bone. Method： Ion exchange method was adopted to prepare Sr-incorporated freeze dried bone.After extraction, L929 cell was used to evaluate cytotoxicity by MTT method. The material was implanted into mouse and abnormal toxicity was then assayed. Result： The Sr density of the novel material is 5.14 %. Cytotoxicity of the material is ranked to nontoxic class and no abnormal toxicity effect was observed. Conclusion： Sr-incorporated freeze dried bone is a comparatively safe novel bone substitute. |
| Keywords: | allograft： freeze dried bone： strontium biological safety |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |