Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes |
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| Authors: | Persson M Friederich Franzén S Catrina S-B Dallner G Hansell P Brismar K Palm F |
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| Affiliation: | (1) Department of Medical Cell Biology, Biomedical Center, Husargatan 3, Box 571, 751 23 Uppsala, Sweden;(2) Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden;(3) Department of Medical and Health Sciences, Link?ping University, Link?ping, Sweden |
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| Abstract: | Aims/hypothesis Increased oxygen consumption results in kidney tissue hypoxia, which is proposed to contribute to the development of diabetic nephropathy. Oxidative stress causes increased oxygen consumption in type 1 diabetic kidneys, partly mediated by uncoupling protein-2 (UCP-2)-induced mitochondrial uncoupling. The present study investigates the role of UCP-2 and oxidative stress in mitochondrial oxygen consumption and kidney function in db/db mice as a model of type 2 diabetes. |
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