Serum interleukin-1 beta is increased in cluster headache |
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| Authors: | Paolo Martelletti Massimo Granata Mario Giacovazzo |
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| Affiliation: | Headache Centre, Institute of Internal Medicine VI, University "La Sapienza", Rome, Italy |
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| Abstract: | We measured serum interleukin-l beta (IL-1 beta) in 24 episodic cluster headache (CH) patients and 45 normal controls using a specific ELISA method. There was an increase in IL-1 beta in all CH patients compared to controls. IL-1 beta was further increased during the ictal phase of CH compared to patients between attacks and normal individuals. Between attacks, IL-1 beta was also significantly increased compared to controls. We suggest that these results represent an activation of the immune system in CH. |
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