Marked changes in red cell volume response to isotonic glucose solution during storage |
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| Authors: | N Tatsumi I Tsuda |
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| Institution: | Department of Clinical and Laboratory Medicine, Osaka City University Medical School, Japan. |
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| Abstract: | The changes of erythrocyte-volume caused by isotonic hexose solutions, glucose and galactose, during storage were studied. Blood was stored for 13 weeks at 4 degrees C. The determinations were carried out using a newly developed blood cell volume analyzer which can measure the continuous changes in cell volume. The erythrocyte volume gradually increased and reached a plateau after 13 weeks of storage. The percent volume increase in hexose solutions markedly decreased during the first 4 weeks of storage. These changes may have been due to denaturation of the membrane protein responsible for hexose permeation during storage. |
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