基于18F-FDG PET/CT显像分析非小细胞肺癌纵隔淋巴结转移的危险因素

目的基于PET/CT显像分析非小细胞肺癌(NSCLC)纵隔淋巴结转移与临床各项指标的关系,探讨纵隔淋巴结转移的危险因素。方法收集接受PET/CT检查的初诊NSCLC患者130例。采用单因素分析纵隔淋巴结转移与性别、年龄、吸烟状况、原发灶最大标准摄取值(SUVmax)、大小、病理类型及分化程度之间的关系,采用多因素Logistic回归分析NSCLC纵隔淋巴结转移的危险预测因素。结果 68例出现区域淋巴结转移。单因素分析得出纵隔淋巴结转移与肺癌原发灶SUVmax、大小、分化程度有关(P<0.05),与年龄、性别、吸烟状况及病理类型无关(P>0.05);多因素Logis-tic回归分析显示仅原发灶SUVmax是影响纵隔淋巴结转移的独立因素。结论NSCLC纵隔淋巴结转移与原发灶SUVmax、大小及分化程度有关;原发灶SUVmax是NSCLC纵隔淋巴结转移的一个独立危险预测因素。

Analysis of risk factors for mediastinal lymph nodes metastases in non-small cell lung cancer patients with 18F-FDG PET/CT

Objective To observe the relationship between mediastinal lymph nodes metastasis and various clinical indexes based on the 18F-FDG PET/CT imaging,in order to explore the risk factors for malignant lymph nodes in non-small cell lung cancer(NSCLC).Methods A total of 130 patients with NSCLC diagnosed in the first visit and underwent 18F-FDG PET/CT were retrospectively reviewed.The relationship between mediastinal lymph nodes metastasis and gender,age,smoking status,primary tumor maximum standardized uptake value(SUVmax),size,pathological types and differentiation degree were analyzed,and risk factors for mediastinal lymph node metastasis in NSCLC were assessed by Muilivarivate Logistic regression.Results Regional lymph nodes metastasis was found in 68 of 130 NSCLC patients.Mediastinal lymph nodes metastasis correlated with SUVmax,size and differentiation degree in primary lung lesion(P<0.05),while there was no correlation with gender,age,smoking status and pathological type(P>0.05).Further adopting Muilivarivate Logistic regression analysis showed that only SUVmax was an independent factor for lymph nodes metastasis.Conclusion Mediastinal lymph nodes metastasis correlated with SUVmax,size and differentiation degree in primary lung lesions.High SUVmax is an independent predictor of lymph nodes metastasis in NSCLC patients.