| 原花青素柔性纳米脂质体与普通脂质体体外释药评析 |
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| 引用本文： | 陈燕军,武惠斌,袁军林,石磊,金日显,刘华凤,熊维政,黄璐琦.原花青素柔性纳米脂质体与普通脂质体体外释药评析[J].中国中药杂志,2010,35(2):169-172. |
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| 作者姓名： | 陈燕军 武惠斌 袁军林 石磊 金日显 刘华凤 熊维政 黄璐琦 |
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| 作者单位： | 1. 中国中医科学院,中药研究所,北京,100700
2. 河南羚锐制药股份有限公司,河南,新县,465550 |
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| 基金项目： | 中国博士后科学基金项目(20080430532) |
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| 摘 要： | 目的:制备原花青素柔性纳米脂质体,探索其与普通脂质体体外释药特性.方法:采用薄膜分散法制备脂质体混悬液,采用透射电镜观察其形态;以总酚的含量作为评价指标,采用动态透析法考察其在不同介质中的释药特性.结果:原花青素柔性纳米脂质体、普通脂质体体外释药特性均符合Weibull模型.结论:在没有压力条件下,原花青素柔性纳米脂质体与普通脂质体具有相似的体外释药特性.
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| 关 键 词： | 原花青素 柔性纳米脂质体 普通脂质体 体外释药 |
| 收稿时间： | 2009/8/10 0:00:00 |
Comparison of in vitro release behavior of proanthocyanidins flexiblenanoliposomes and general nanoliposomes |
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| CHEN Yanjun,WU Huibin,YUAN Junlin,SHI Lei,JIN Rixian,LIU Huafeng,XIONG Weizheng and HUANG Luqi.Comparison of in vitro release behavior of proanthocyanidins flexiblenanoliposomes and general nanoliposomes[J].China Journal of Chinese Materia Medica,2010,35(2):169-172. |
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| Authors: | CHEN Yanjun WU Huibin YUAN Junlin SHI Lei JIN Rixian LIU Huafeng XIONG Weizheng and HUANG Luqi |
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| Institution: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China;Henan Lingrui Pharmaceutical Company Ltd., Xinxian 465550, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China;Henan Lingrui Pharmaceutical Company Ltd., Xinxian 465550, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China;Henan Lingrui Pharmaceutical Company Ltd., Xinxian 465550, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China |
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| Abstract: | Objective : To prepare flexible proanthocyanidins nanoliposomes,and explore the in vitro release behavior of proanthocyanidins flexible nanoliposomes and general nanoliposomes. Method :Flexible proanthoeyanidins nanoliposomes were prepared proanthocyanidins using a film dispersion method,characterized by transmission electron microscope,and the in vitro release action was studied in different dissolution mediums using dynamic dialyse method with the content of total phenol as index. Result : The in vitro release of both proanthocyanidins flexible nanoliposomes and general nanoliposomes were in accordance with Weibull distribution. Conclusion : Proanthocyanidins flexible nanoliposomes without pressure had similar in vitro release behavior with general nanoliposomes. |
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| Keywords: | proanthocyanidins flexible nanoliposomes general nanoliposomes drug release in vitro |
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