| 脂肝康药效学研究 |
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| 引用本文： | 岳 南,只德广,赵益桂,苏 雅,陈芙蓉.脂肝康药效学研究[J].医学教育探索,2010,33(6):416-449. |
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| 作者姓名： | 岳 南 只德广 赵益桂 苏 雅 陈芙蓉 |
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| 作者单位： | 天津药物研究院 新药评价中心,天津 300193 |
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| 摘 要： | 目的：观察脂肝康对动物实验性脂肪肝的治疗作用。方法：采用乙硫氨酸、高脂饲料复制动物脂肪肝模型,iv高分子右旋糖苷复制大鼠“血瘀”模型,观察脂肝康的作用。结果：脂肝康能明显降低实验性脂肪肝动物肝脏、血液中的总胆固醇（TC）、三酰甘油（TG）的量;明显抑制“血瘀”大鼠全血粘度的升高。结论：脂肝康对脂肪肝大鼠有明显的治疗作用。
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| 关 键 词： | 血瘀 脂肪肝 TC TG 脂肝康 |
Pharmacodynamic study of Zhigankang |
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| YUE Nan,ZHI De-guang,ZHAO Yi-gui,SU Y,CHEN Fu-rong.Pharmacodynamic study of Zhigankang[J].Researches in Medical Education,2010,33(6):416-449. |
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| Authors: | YUE Nan ZHI De-guang ZHAO Yi-gui SU Y CHEN Fu-rong |
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| Institution: | Center for Drug Evaluation and Research, Tianjin Institute of Pharmaceutical Reseach, Tianjin 300193, China |
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| Abstract: | Objective: To investigate the therapeutic effect of Zhigankang on experimental fatty liver. Methods: To observe the effect of Zhigankang on "blood stasis" of rats that were fed with ethionine, high-fat food, or by iv injection of high molecular Dextran. Results: Zhigankang significantly reduced TC and TG content in liver and blood of rats and inhibited the increase of whole blood viscosity in "blood stasis" rats. Conclusion: Zhigankang has obvious therapeutic effect on fatty liver in rats |
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| Keywords: | blood stasis fatty liver TC TG Zhigankang |
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