| 维生素E对肿瘤坏死因子损伤主动脉内皮细胞的防治作用 |
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| 引用本文： | 王福俤 和 红. 维生素E对肿瘤坏死因子损伤主动脉内皮细胞的防治作用[J]. 同济大学学报(医学版), 1999, 20(3): 4 |
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| 作者姓名： | 王福俤 和 红 |
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| 作者单位： | 1. 第二军医大学海军卫生学教研室,上海,200433
2. 上海第二医科大学卫生事业管理系,上海,200025 |
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| 摘 要： | Objective Toexplore the possible mechanism of vitamin E against atherosclerosis through its preventiveeffect on tumor necrosis factor (TNF) inducing endothelial cell injury.Methods Bovineaortic endothelial cells were incubated in culture media with TNF-alpha (400 U/ml) andvitamin E (12.5 microM, 25.0 microM and 50.0 microM respectively) for 72 h.The morphology,proliferation, apoptosis and adherence of endothelial cells were investigated withphase-contrast microscope, MTT method, flow cytometry analysis and cell countrespectively.Results Compared with TNF group, the phenomena ofendothelial cell deformity and shedding were slighter, the number of adhered HL60 monocytecells and G1-phase cells were less, and the inhibitory rate and the apoptoticpeaks were significantly lower in vitamin E groups.Conclusion Theresults suggested that vitamin E has definite protective effects on injury induced by TNFas shown in morphology, proliferation and apoptosis of endothelial cells in vitro.
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| 关 键 词： | 维生素E；内皮细胞；肿瘤坏死因子；细胞增殖；细胞凋亡 |
| 修稿时间： | 1998-11-04 |
Rolesof Vitamin E on the Protection against Aortic EndothelialCell Injury Induced by Tumor Necrosis Factor in vitro |
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| Wang Fudi,He Hong. Rolesof Vitamin E on the Protection against Aortic EndothelialCell Injury Induced by Tumor Necrosis Factor in vitro[J]. Journal of Tongji University(Medical Science), 1999, 20(3): 4 |
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| Authors: | Wang Fudi He Hong |
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