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复合抗氧化剂对糖尿病人餐后血糖及血胰岛素水平的影响
引用本文:朱翠凤,张帆,蓝薇,徐晓燕,郭松超,苏宜香. 复合抗氧化剂对糖尿病人餐后血糖及血胰岛素水平的影响[J]. 营养学报, 2004, 26(3): 196-200
作者姓名:朱翠凤  张帆  蓝薇  徐晓燕  郭松超  苏宜香
作者单位:1. 北京大学深圳医院营养科,518036,深圳
2. 北京大学深圳医院内分泌科,518036,深圳
3. 广西医科大学公共卫生学院营养系,530021,南宁
4. 中山大学公共卫生学院营养系,510080,广州
基金项目:广西科技厅科技攻关项目(桂科攻0322025-6)
摘    要:目的: 观察大豆异黄酮(SI)、维生素C (VC)、维生素E (VE)等复合抗氧化剂对2型糖尿病(T2DM)患者餐后血糖及血胰岛素的影响。方法: 将96例(男女各半)T2DM患者按性别随机分为非干预组(B组)、低(C组)、中(D组)和高剂量(E组)复合抗氧化剂干预组,并设正常对照组(A组,n=24,男女各半)。检测各组在口服葡萄糖耐量试验(OGTT)前后0、1、2、4、6 h的血糖及胰岛素水平,计算男女各组的血糖及胰岛素6h曲线下面积(AUC)。结果: OGTT后,正常对照组男性的血胰岛素和血糖AUC均高于女性;但都明显低于四个糖尿病研究组。而糖尿病组男女性的C、D、E组血胰岛素AUC E均低于B组。血糖AUC : 男女性的D组和E组均低于C组、B组。女性的血糖和血胰岛素AUC E组与B组比较差异显著。男女两性血糖的增值D组和E组均显著低于B组和C组。 结论: 中剂量和高剂量的SI、VC、VE复合抗氧化剂可抑制T2DM患者糖负荷后活性氧自由基所介导的葡萄糖氧化反应,提高机体对胰岛素的敏感性,对餐后血糖和血胰岛素水平的变化均有改善的倾向,且女性较男性更为敏感。

关 键 词:复合抗氧化剂  大豆异黄酮  活性氧自由基  胰岛素曲线下面积  血糖曲线下面积
文章编号:0512-7955(2004)03-0196-05
修稿时间:2004-01-06

EFFECT OF COMPOUND ANTIOXIDANTS ON POSTPRANDIAL GLUCOSE AND INSULIN OF TYPE 2 DIABETES MELLITUS PATIENTS
ZHU Cui-feng,ZHANG Fan,LAN Wei,XU Xiao-yan,GUO Song-chao,SU Yi-xiang. EFFECT OF COMPOUND ANTIOXIDANTS ON POSTPRANDIAL GLUCOSE AND INSULIN OF TYPE 2 DIABETES MELLITUS PATIENTS[J]. Acta Nutrimenta Sinica, 2004, 26(3): 196-200
Authors:ZHU Cui-feng  ZHANG Fan  LAN Wei  XU Xiao-yan  GUO Song-chao  SU Yi-xiang
Affiliation:ZHU Cui-feng,ZHANG Fan1,LAN Wei1,XU Xiao-yan1,GUO Song-chao2,SU Yi-xiang3
Abstract:Objective: To observe the co-effect of antioxidant compound, soybean isoflavone (SI), VC and VE on glucose and insulin response after oral glucose load in Type 2 Diabetes Mellitus (T2DM) . Methods: 96 selected T2DM patients (50% male, 50% female) were randomly divided into 4 groups according to the dosage of the compound given , none (group B), low dosage (group C), medium dosage (group D) and high dosage (group E) . The normal control (group A) included 24 persons half male, half female . Blood glucose and insulin were determined at OGTT 0 h, 1 h, 2 h, 4 h, 6 h, and the areas under the curve (AUC) of blood insulin/glucose were calculated. Results: The AUC of blood insulin/glucose of male was higher than female in control group, but both were lower than those of four diabetes groups. In both genders of the diabetes groups, blood insulin AUC of group C, D, E was lower than group B, blood glucose AUC of group D, E was lower than group C and B. There was significant difference in blood insulin and glucose AUC of group E as compared to group B in female (P< 0.05). The increment of glucose in both genders of group D and E was lower than that in group B and C. Conclusion: Female insulin sensitivity was higher than male in control group after OGTT. For diabetes, both genders showed decreased insulin sensitivity, and no significant postprandial glucose change. Medium and high dosage of the antioxidant compound of SI, VC and VE could improve the postprandial glucose and insulin sensitivity, and inhibit glucose oxidation after oral glucose load in diabetes, female even better than male.
Keywords:antioxidant compound  soy isoflavone  diabetes mellitus
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