树突状细胞联合化疗治疗老年人晚期恶性肿瘤的临床观察

目的：探讨同源异体肿瘤抗原致敏的树突状细胞联合化疗治疗中老人晚期恶性肿瘤的临床疗效、不良反应。方法：对开展树突状细胞体外培养技术以来。联合化疗治疗经细胞学或病理学确诊的晚期或复发肿瘤25例，分离患者外周血单核细胞和淋巴细胞在体外培养成树突状细胞（dendritic cell DC），化疗结束后行树突状细胞治疗，观察指标有客观缓解率、临床获益率和不良反应。结果：25例中有2例达CR，4例达PR，2例MR，SD11例，无效2例，4例PD，未发现Ⅲ级以上的不良反应。结论：树突状细胞联合化疗治疗老年肿瘤患者安全性好，能降低化疗的不良反应，并改善患者的临床症状，提高免疫功能，改善生存质量。

Clinical observation of dendritic cell vaccination combined with chemotherapy in elderly patients with advanced malignant tumor

Objective:To study the clinical effect and adverse reaction of dendritic cell(DC)vaccination combined with chemothera- py in elderly patients with advanced malignant tumor.Methods:25 elderly patients with advanced or recurrent malignant tumor confirmed by cytology or pathology were enrolled since 2005,matured DCs were derived from peripheral blood monocytes and loaded tumor lysate, DCs were injected in a lymph mode and intromitted by peripheral vessel after chemotherapy.The objective remission rate,tumor marker profile and adverse reaction were determined respectively.Results:The therapy resulted in 2 cases complete remission,4 partial remission,2 minal remission,11 stable disease,2 no change and 4 progressive disease.The serious adverse reaction was not found.Conclusion:Dendritic cell vaccination combined with chemotherapy in elderly patients with advanced malignant tumor is an affective and safe comprehensive method,and can decrease the adverse reaction of chemotherapy,enhance the immune function and improve the quality of life.