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| 血清IGF-1和VEGF水平与糖尿病足关系的研究 | |
| 引用本文： | 汤学夫,孙劲松,李红辉,何琴,柯新桥.血清IGF-1和VEGF水平与糖尿病足关系的研究[J].中国优生与遗传杂志,2006,14(5):22-23. |
| 作者姓名： | 汤学夫 孙劲松 李红辉 何琴 柯新桥 |
| 作者单位： | 1. 深圳市罗湖区人民医院,检验科,深圳,518001 2. 深圳市罗湖区人民医院,中医科,深圳,518001 3. 深圳市罗湖区人民医院,内分泌科,深圳,518001 4. 深圳市罗湖区人民医院,东门门诊,深圳,518001 |
| 摘 要： | 目的研究糖尿病足患者血清IGF-1和VEGF水平与糖尿病足部溃疡或坏疽的关系。方法分别采用放射免疫分析法和定量双抗体夹心ELISA法检测23例糖尿病足患者血清IGF-1和VEGF水平,并与健康人和2型糖尿病患者进行比较。结果糖尿病足患者血清IGF-1和VEGF水平显著低于糖尿病患者和健康对照组(P<0.05)。结论生长因子IGF-1和VEGF是糖尿病足发生和发展的重要影响因素,IGF-1和VEGF水平低下可能是糖尿病足部溃疡经久不愈的重要原因。 |
| 关 键 词： | 糖尿病足 胰岛素样生长因子-1 血管内皮生长因子 |
| 文章编号： | 1006-9534(2006)05-0022-02 |
| 修稿时间： | 2005年11月24 |
Plasma level of IGF-1 and VEGF in patients with diabetic foot |
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| TANG Xue-fu,SUN Jin-song,LI Hong-hui,HE Qin,KE Xin-qiao.Plasma level of IGF-1 and VEGF in patients with diabetic foot[J].Chinese Journal of Birth Health & Heredity,2006,14(5):22-23. | |
| Authors: | TANG Xue-fu SUN Jin-song LI Hong-hui HE Qin KE Xin-qiao |
| Abstract: | objective: To investigate the correlation of the serum concentration of insulin-like growth factor-1(IGF-1) and vascular endothelial growth factor(VEGF) in diabetic foot patients with the incidence of diabetic foot ulcer or necrosis.Methods: The serum concentration of IGF-1 and VEGF in 23 diabetic foot patients were determined with radioimmunoassay and enzyme linked immunosorbent assay (ELISA) for quantitative analysis respectively and compared with that of normal subjects and type 2 diabetes patients.Results: The serum concentration of IGF-1 and VEGF in patients with diabetic foot were obviously lower than those of diabetic and normal control group(P<0.05).conclusion: IGF-1 and VEGF have an important effect on the occurrence anddevelopment of diabetic foot,the lower levers of IGF-1 and VEGF may be the important cause that diabetic foot ulcer can not cicatrize for a long time. |
| Keywords: | Diabetic foot Insulin-like growth factor-1(IGF-1) Vascular endothelial growth factor(VEGF) |
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