| 血清sVCAM-1水平与2型糖尿病脑梗死关系探讨 |
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| 引用本文： | 韩华,耿芹. 血清sVCAM-1水平与2型糖尿病脑梗死关系探讨[J]. 山西临床医药, 2009, 0(20): 1827-1828 |
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| 作者姓名： | 韩华 耿芹 |
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| 作者单位： | 山东省淄博市中心医院内分泌科 |
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| 摘 要： | 目的:探讨血清中可溶性血管细胞黏附分子-1(sVCAM-1)水平与2型糖尿病(T2DM)患者并发脑梗死的关系探讨。方法:应用ELISA法检测了68例T2DM患者血浆sVCAM-1水平,并且与20例健康人作对照。结果:T2DM各组血清sVCAM-1水平明显高于健康对照组(P<0.01);无脑梗死组、小灶性脑梗死组、大面积脑梗死组含量逐步升高(P<0.01);血清sVCAM-1水平与LDL-C、TG、TC呈正相关(P<0.05)。结论:血清sVCAM-1参与2型糖尿病脑血管并发症的发生与发展,可作为早期2型糖尿病脑血管并发症发生的预测及检测指标。
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| 关 键 词： | 2型糖尿病 可溶性血管细胞黏附分子-1 血管病变 |
Study on changes of Soluble Vascular Cell Adhesion Molecule-1 in Type 2 Diabetes Mellitus |
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| Han Hua,Geng Qin. Study on changes of Soluble Vascular Cell Adhesion Molecule-1 in Type 2 Diabetes Mellitus[J]. Shanxi Clinical Medicine, 2009, 0(20): 1827-1828 |
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| Authors: | Han Hua Geng Qin |
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| Affiliation: | (Department of Endocrinology,Zibo Ce ntral Hospital, Zibo255036,Shandong ,China) |
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| Abstract: | Objective:To investgate the relationship between soluble vascular cell adhesion molecule-1(sVCAM-1) in type 2 diabetes mellitus(T2DM). Methods:Plasma levels of sVCAM-1were measured by ELISA in 68 T2DM patients and 20 healthy controls. Results The plasma levels of sVCAM-1 in T2DM patients were much higher than those in healthy controls (P<0.01).The plasma levels of sVCAM-1 in T2DM patients with cerebral infarction were higher than those in T2DM patients without vascule complication (P<0.01). sVCAM-1 had positive correlation with LDL-C、TG、TC(P<0.05).Conclusions :Serum sVCAM-1 might participate in the course of diabetic microangiopathy |
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| Keywords: | Type 2 diabetes mellitus Soluble vascular cell adhesion molecule-1 Vascule complication |
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