| 丝裂霉素和卡介苗素膀胱内灌注预防膀胱癌术后复发的疗效观察 |
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| 引用本文： | 方伟杰,张斌斌,蔡松良.丝裂霉素和卡介苗素膀胱内灌注预防膀胱癌术后复发的疗效观察[J].浙江医学,2002,24(6):328-329. |
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| 作者姓名： | 方伟杰 张斌斌 蔡松良 |
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| 作者单位： | 1. 325200 瑞安,温州医学院附属第三医院泌尿外科
2. 浙江大学医学院附属第一医院泌尿外科 |
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| 摘 要： | 目的：探讨提高膀胱癌的治疗效果，降低术后复发率的更佳膀胱内灌注方案。方法：将42例行经尿道膀胱肿瘤电切术（TURBt）的浅表性膀胱癌分为两组：A组（21例）膀胱内灌注丝裂霉素加卡介苗素，B组（21例）膀胱内单纯灌注丝裂霉素。两组均在术后1周内开始灌注，每周1次，共6次，然后每月1次，共2年。结果：随访12－28个月，A组复发1例，复发率4．8％，B组复发7例，复发率33．3％，两组复发率的并另有显著性意义（P＜0．05）。结论：丝裂霉素C加卡介苗素膀胱内灌注能明显减少膀胱癌的术后复发。
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| 关 键 词： | 丝裂霉素 卡介苗素 膀胱内灌注 预防 膀胱癌 术后复发 疗效观察 |
| 修稿时间： | 2001年9月27日 |
Prevention of recurrence of bladder cancer by intravesical instillation with combination of Mitomycin C and Bacillus Calmette-Guerir after TURBt |
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| FANG Weijie,ZHANG Binbin,CAI Songliang.Prevention of recurrence of bladder cancer by intravesical instillation with combination of Mitomycin C and Bacillus Calmette-Guerir after TURBt[J].Zhejiang Medical Journal,2002,24(6):328-329. |
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| Authors: | FANG Weijie ZHANG Binbin CAI Songliang |
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| Institution: | FANG Weijie,ZHANG Binbin,CAI Songliang.Department of Urology,Third Affiliated Hospital of Wenzhou Medical College,Zhejiang Ruian 325200,China |
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| Abstract: | Objective To improve the effect of intravesical instillation treatment and reduce the postoperation recurrence rate of bladder cancer.Methods Forty two patients with bladder cancer after TURBt were divided into two groups to receive intravesical instillation treatment with combination of Mitomycin C and Bacillus Calmette_Guerir(BCG) or Mitomycin C alone respectively after operation.Results All these patients were following up from 12 to 28 months.Recurrence rate in the group treated with combination of Mitomycin and BCG was 4.8%(1/21) and 3.3%(7/21) in the group treated with Mitomycin C alone(P<0.085).Conclusion Intravesical instillation with Mitomycin C combination with BCG may be the more effective therapy in prevention of recurrence after TURBt. |
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| Keywords: | Bladder tumor Mitomycin C Bacillus calmette_Guerir |
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