29例多重耐药铜绿假单胞菌感染的耐药性分析

目的了解多重耐药铜绿假单胞菌耐药性特点,为临床治疗多重耐药铜绿假单胞菌感染提供参考依据。方法美国BD phoenix 100全自动细菌鉴定药敏检测系统数据库2013年数据并应用WHONET5.5细菌耐药监测软件进行回顾性统计分析。结果痰液标本中分离出多重耐药铜绿假单胞菌比例最高,高达68.97%,并分别对氨苄西林、头孢唑林、头孢噻肟、氨苄西林/舒巴坦、复方新诺明、氯霉素100.00%耐药,多黏菌素B耐药率0.00%亚胺培南耐药率3.45%、美罗培南耐药率3.45%,头孢他啶耐药率6.90%,环丙沙星耐药率10.34%。结论多黏菌素B表现最敏感,碳青霉烯类如亚胺培南、美罗培南,头孢他啶,喹诺酮类如环丙沙星,这些都是抗多重耐药铜绿假单胞菌较好的抗生素。重症感染患者建议联合用药,初次用药3⁴ d内易发展为耐药株,加强耐药监测,指导临床合理用药。

29 Cases of Multiple Drug-resistant Resistance Analysis of Pseudomonas Aeruginosa Infection

Objective Understanding of multiple drug resistance pseudomonas aeruginosa resistance characteristics, for the clinical treatment of multiple drug resistance pseudomonas aeruginosa infection to provide the reference basis. Methods the BD phoenix 100 automatic bacteria identification application database data in 2013 and drug susceptibility testing system WHONET5.5 retrospective statistical analysis of bacterial drug resistance monitoring software. Results Isolated from the sputum specimens of multiple drug resistant pseudomonas aeruginosa, the highest proportion is as high as 68.97%, and respectively to ampicillin and cefazolin, cefotaxime, ampieillin and compound new Ming shu ba, 100.00% chloramphenicol resistant, polymyxin B resistance to imine pei south percentages of 0.00% to 3.45%, the United States e.faecalis resistant rate 3.45%, he totally cephalosporin resistant rate 6.90%, ciprofloxacin resistance to 10.34%. Conclusions Polymyxin B to perform the most sensitive, carbon black alkene like imide, south beauty and e.faecalis cephalosporins he totally, quinolone like ciprofloxaein, these are resistant to multiple drug resistant pseudomonas aeruginosa better antibiotics. Severe infection patients suggest combination, easy to use drug first 3-4 days for the development of resistant strains, to strengthen the resistant monitoring and to guide clinical rational drug use.