20例动脉粥样硬化性患者临床治疗的探讨

动脉粥样硬化是动脉硬化中常见、重要的类型。本病主要累及大型及中型的肌弹力型动脉,以主动脉,冠状动脉、脑动脉和四肢大动脉为多见,常导致管腔闭塞或管壁破裂出血等严重后果。其特点是动脉发生了非炎症性、退行性和增生性的病变,导致管壁增厚变硬,失去弹性和管腔缩,动脉粥样硬化的病理变化主要累及循环系统的大型弹力型动脉如主动脉、肺动脉、椎动脉等中型肌弹力型动脉如冠状动脉和脑动脉。受累动脉的病变从内膜开始,先后有多种病变同时存在,包括局部有脂质和复合糖类积聚、出血和血栓形成、纤维组织增生和钙质沉着,并有动脉中层的逐渐退化和钙化。现代细胞分子生物学技术显示,动脉粥样硬化病变均具有平滑肌细胞增生、大量胶原纤维、弹力纤维和蛋白多糖等结缔组织基质形成以及细胞内外脂质积聚的特点,由于在动脉内膜积聚的脂质外观呈现黄色粥样,因此称为动脉粥样硬化。

Atherosclerotic Patients a Clinical Study of 20 Cases

Atherosclerosis is the common and important type disease.The disease mainly involve large and medium-sized muscular elastic arteries.The aorta and cerebral arteries and coronary arteries is more common limbs,Often leads to luminal occlusion or rupture of the wall and other serious consequences.Characterized by the occurrence of non-inflammatory arterial degenerative and proliferative lesions lead to loss of elasticity of wall thickening and luminal narrowing harden.Atherosclerosis of the major pathological changes involving the circulatory system of a large elastic arteries such as aorta,pulmonary artery,vertebral artery of the medium-sized elastic arteries.such as coronary artery disease cerebral artery are involved from the beginning,there have been many endometrial lesions exist,including a local accumulation of blood lipids and complex carbohydrates and fibrous tissue hyperplasia and thrombosis and have calcinosis the gradual degradation of the middle and arterial calcification.Modern cell and molecular biology techniques show that atherosclerotic lesions have a large number of smooth muscle cell proliferation and collagen fibers elastic fibers and other connective tissue proteoglycan matrix formation and accumulation of intracellular lipid characteristics as the accumulation of lipid in the arterial intima yellow appearance so called atherosclerosis atherosclerosis.