济川凿岩散联合FolFox4方案治疗晚期结直肠癌疗效观察

目的观察济川凿岩散联合FolFox4方案治疗晚期结直肠癌的临床疗效。方法回顾性分析24例晚期结直肠癌患者化疗的临床资料。化疗方案均采用FolFox4方案,于化疗期间和化疗后两周配合服用济川凿岩散,观察近期疗效、毒副反应及生存质量变化。结果近期疗效中CR3例,PR6例,SD12例,PD3例,总有效率(CR+PR)9例,占37.5%;而受益率(CR+PR+SD)21例,占87.5%;毒副反应以恶心、呕吐、腹泻为主,多为轻至中度,骨髓抑制为轻至中度,患者耐受性良好。生存质量上,治疗前后比较卡氏评分有所增加,但卡氏评分增加10分,因此生存质量稳定。结论济川凿岩散联合FolFox4方案治疗晚期结直肠癌,对部分失去手术机会或年老体衰无法承受手术的患者,通过保守治疗,可减毒增效,并在一定程度上提高生存质量。

Observation ofthe efficacy of Jichuan Zaoran San combined with FOLFOX4 chemotherapy for the treatment of advanced-stage colorectal cancer

Objective To evaluate the efficacy of Jichuan Zaoran San combined with FOLFOX4 chemotherapy for the treatment of advanced colorectal cancer.Methods Twenty four patients of advanced-stage colorectal cancer patients were aretrospective analyzed,all of whom were treated using FOLFOX4 chemotherapy regimen.Herbs prescribed complying with the method of Jichuan Zaoran San were applied during chemotherapy and for 2 weeks after completion of chemotherapy.Recent treatment effects,toxic side-effects and changes in quality of life were observed.Results Of the recent treatment effects,3 samples were CR,6 samples were PR,12 samples were SD,3 samples were PD,9 samples were CR＋PR,which constituted 37.5%.21 samples were CR＋PR＋SD,which constituted 87.5%.Toxic side-effects mainly included nausea,vomiting and diarrhea,most of which were light to medium degree.Bonem arrow suppression effects were mostly light to medium degree.In general,all patients had good tolerance.In as-sessment of patients＇ quality of life,Karnofsky score after treatments decreased as compared to that before treatments.Since the decrease in Karnofsky score was＆lt;10,the quality of life was considered as stable. Conclusion Applying the method of Jichuan Zaoran San combined with FOLFOX4 chemotherapy in treatment of advanced-stage colorectal cancer,which may enable patients who lost the opportunity of operation or originally unable to tolerate chemotherapy due to old age to regain treatment opportunities,might reduce toxicity and enhance treatment effects,as well as elevate patients＇quality of life.