中性粒细胞淋巴细胞比值和血小板淋巴细胞比值对调强放疗鼻咽癌患者的预后价值

目的 研究中性粒细胞淋巴细胞比值(NLR)与血小板淋巴细胞比值(PLR)对鼻咽癌(NPC)调强放疗患者的预后价值。 方法 回顾性收集2012年6月至2014年1月期间就诊的120例调强放疗鼻咽癌患者的一般临床信息及淋巴细胞、中性粒细胞、血小板计数和生存资料。选择相关性分析、K-M生存分析和Cox多因素回归分析、探讨NLR、PLR与患者总生存时间(OS)、无进展生存时间(PFS)、无远处转移生存时间(DMFS)、局部无复发生存时间(LRF)的关系。 结果 患者5年OS、PFS、LRF和DFS分别为86.8%、78.3%、94.2%和85.3%,NLR与T期、N期、肿瘤期相关,PLR与T期、肿瘤期相关。NLR是OS、PFS、DMF的独立预后指标。 结论 NLR是调强放疗鼻咽癌患者的独立预后因素。

The prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intensity modulated radiation therapy for nasopharyngeal carcinoma

Objective To evaluate the role of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)in the prognosis of nasopharyngeal carcinoma(NPC). Methods A total of 120 patients with NPC undergoing intensity modulated radiation therapy(IMRT)from June 2012 to January 2014 were retrospectively included and their clinical information was obtained. The relationship between NLR, PLR, and overall survival(OS), progression-free survival(PFS), distant metastasis-free survival(DMFS), and local recurrence-free survival(LRF)was explored by correlation analysis, survival analysis, and multivariate regression analysis. Results The overall 5-year estimated OS, PFS, LRFS and DFS were 86.8%, 78.3%, 94.2%, and 85.3%, respectively. There was a significant association between NLR and T-stage, N-stage and tumor stage. PLR was also significantly associated with T-stage and tumor stage. NLR was shown to be an independent prognostic indicator for OS, PFS, DMFS. Conclusion NLR is an independent prognostic factor in nasopharyngeal carcinoma patients treated with IMRT.