0.1%双氯芬酸钠滴眼液在SMILE术后疗效的观察

目的探讨飞秒激光小切口基质透镜取出术(SMILE)术后应用0.1%双氯芬酸钠滴眼液的安全性、有效性及耐受性。方法接受SMILE的60例(60只眼)近视患者分为试验组、对照组。30只眼/组。试验组患者SMILE术后10 d应用地塞米松/妥布霉素滴眼液4次/d,术后第11天开始改为应用0.1%双氯芬酸钠滴眼液滴眼液4次/d,至术后30 d;对照组患者SMILE术后应用地塞米松/妥布霉素滴眼4次/d应用10 d。所有患者在术前及术后10 d、术后1个月进行检查,包括裸眼视力、眼压、角膜地形图与不良反应。两组间观察指标比较采用单因素方差分析(one-way ANOVA),P值<0.05认为差异存在显著统计学意义。结果两组患者在术后10 d裸眼视力差异无显著统计学意义(P=0.12,F=2.50),试验组患者在术后1 m裸眼视力优于对照组,差异具有显著统计学意义(P=0.001,F=29.78)。两组患者术前、术后10 d、术后1个月后眼压差异无显著统计学意义(P值分别为0.45、0.97、0.66,F值分别为0.56、<0.001、0.19)。两组患者在术前角膜地形图SRI、SAI指数、术后1 m角膜地形图SRI指数方面差异无显著统计学意义(P值分别为0.32、0.05、0.07,F值分别为1.01、3.86、3.27),试验组患者在术后1个月角膜地形图SAI指数优于对照组,差异具有显著统计学意义(P=0.01,F=7.70)。8例(26.67%)试验组患者存在用药后一过性烧灼感,其后症状可缓解,未停药。余各组患者术后各时间段均无其他不适主观症状与不良反应发生。结论 0.1%双氯芬酸钠滴眼液用于SMILE术后可辅助糖皮质激素应用,安全、有效,在促进术后视力、眼表恢复方面均可获得满意的效果。

Efficacy of 0.1% diclofenac sodium eye drops post-SMILE

Objective To study the safety, efficacy, and tolerability of 0.1% diclofenac sodium eye drops after the small incision lenticule extraction(SMILE)procedure. Methods Two groups were observed, including 60 patients(60 eyes)with myopia. Thirty patients(30 eyes)were treated with topical compound tobramycin eye drops 4 times daily for 10 days as the control group. Meanwhile, 30 patients(30 eyes)were treated with topical compound tobramycin eye drops 4 times daily for 10 days, and diclofenac sodium eye drops 4 times daily for 20 days. All of the patients were observed in the preoperative and postoperative periods. The visual acuity, intraocular pressure, topography and adverse reactions were recorded at 10 d and after 1 month. The differences between the 2 groups were analyzed by the single factor analysis of variance(one-way ANOVA). Results There was no significant difference between the 2 groups in terms of uncorrected visual acuity at 10 d(P=0.12,F=2.50). However, there was after 1-month(P=0.001,F=29.78). There were no significant differences between the intraocular pressure values pre-operation, and postoperatively at 10 d and 1 month(P=0.45,0.97,0.66,F=0.56,<0.001,0.19). There were no significant differences between the 2 groups in the SRI and SAI values pre-operation and at 1 month in the SRI index(P=0.32, 0.05, 0.07,F=1.01, 3.86, 3.27). However, there was a significant difference in the SAI value 1-month post the operation (P=0.01,F=7.70). Eight patients(26.67%)in the diclofenac sodium eye drops group suffered from transient mild eye pain. However, this discomfort was relieved after a short time. Conclusion Diclofenac sodium eye drops can be an effective treatment combined with corticoids after SMILE. They are safe and were satisfactory in the recovery of visual acuity and ocular surface regularity.