| 三七总苷对重症急性胰腺炎大鼠氧自由基的影响 |
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| 引用本文： | 熊进文,陈耿臻,龚利平,刘忠民,陈玉巧. 三七总苷对重症急性胰腺炎大鼠氧自由基的影响[J]. 中国现代医生, 2008, 46(33): 22-24 |
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| 作者姓名： | 熊进文 陈耿臻 龚利平 刘忠民 陈玉巧 |
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| 作者单位： | 1. 广东省深圳市龙岗区人民医院普外科,广东深圳,518172
2. 汕头大学医学院,广东汕头,515041 |
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| 基金项目： | 深圳市龙岗区科技和信息局资助课题 |
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| 摘 要： | 目的探讨三七总苷对重症急性胰腺炎（SAP）大鼠氧自由基的影响。方法SD大鼠135只，随机分为假手术组、SAP组和三七总苷治疗组，每组45只，通过十二指肠胆胰管逆行加压注射5％牛磺胆酸钠溶液的方法制备大鼠SAP模型，每组造模后又按6、12和24h分为3个时间点。分别在3个组的不同时间点抽血，测定大鼠血清丙二醛（MDA）、超氧化物歧化酶（SOD）、淀粉酶。胰腺病理改变等指标的变化。结果SAP组各个时段血清淀粉酶和MDA水平升高,SOD水平降低，与对照组各个时段比较有统计学差异（P〈0.01）；三七总苷治疗组在6、112和24h3个时间点与SAP组相比，血清淀粉酶和MDA的水平均降低（P〈0.01或P〈0．05），SOD水平升高（P〈0．01）。结论三七总苷通过降低损害因子MDA、升高保护因子SOD，对SAP有治疗作用。
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| 关 键 词： | 重症急性胰腺炎 三七总苷 氧自由基 丙二醛 超氧化物歧化酶 |
Effect of Panax Notoginseng Saponins on Oxygen Free Radicals in Rats with Severe Acute Pancreatisis |
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| XIONG Jinwen,CHEN Gengzhen,GONG Liping,LIU Zhongmin,CHEN Yuqiao. Effect of Panax Notoginseng Saponins on Oxygen Free Radicals in Rats with Severe Acute Pancreatisis[J]. , 2008, 46(33): 22-24 |
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| Authors: | XIONG Jinwen CHEN Gengzhen GONG Liping LIU Zhongmin CHEN Yuqiao |
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| Affiliation: | XIONG Jinwen1 CHEN Gengzhen2 GONG Liping2 LIU Zhongmin1 CHEN Yuqiao11.Department of Surgery,Longgang District People's Hospital of Shenzhen,Guangdong 518172,2.Medical College of Shantou University,Guangdong 515041 |
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| Abstract: | Objective To observe the effects of panax notoginseng saponins on oxygen free radicals in rats with severe acute pancreatitis(SAP). Methods 135 SD rats were randomized into 3 groups: sham-group(n=45),SAP group(n=45) and panax notoginseng saponins treated group(n=45). The models of SAP were made by retrograde infusion of 5% sodium taurocholate into the pancreatic duct of SD rats and each group was timed by 6,12 and 24h after operation dynamically to measure the content changes of plasma malondialdehyde(MDA) ... |
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| Keywords: | Severe acute pancreatitis Panax notoginseng saponins Oxygen free radicals Malondialdehyde(MDA) Superoxide dismutas(SOD) |
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