五味消毒饮治疗大鼠实验性急性鼻咽炎的疗效观察

目的观察五味消毒饮对大鼠实验性急性鼻咽炎的治疗作用。方法SD大鼠30只，应用创伤后金黄色葡萄球菌接种法造成急性鼻咽炎模型，然后随机分成模型对照组、中药治疗组、西药对照组，并平行设置正常对照组分别进行治疗干预。治疗前后测量体温，观测大鼠的行为改变及白细胞变化，同时取鼻咽组织进行病理检查。结果大鼠感染后出现行为异常，白细胞增多。病理检查显示明显急性炎症改变。中药治疗组大鼠各项指标明显改善．与西药对照组相似。结论五味消毒饮对大鼠实验性急性鼻咽炎有良好的治疗作用。

Experimental study on the therapeutic effect of Five-Ingredient Toxin-Dispersing Beverage on acute nasopharyngitis among rats

Objective To investigate the therapeutic effect of Five-Ingredient Toxin-Dispersing Beverage(FITDB) on acute nasopharyngitis experimentally induced by Staphylococcus aureus infecting among rats.Methods Forty SD rats were included in this study,with 30 prepared as the model of acute nasopharyngitis at first induced by bacteria infecting following mechanic injury to nasopharyngeal mucosa and the other 10 taken as healthy controlling group(HCG).Then,these models were randomly divided into three groups with 10 rats in each,i.e.modeling group(MG),treating group(TG) and positive controlling group(PCG) treated by N.S.,FITDB and ampicillin respectively.Observed during the experimental period were body temperature,white blood cell(WBC) number,behavior changes and histopathology of nasopharyngeal mucosa and followed were a comparative analysis on the differences in these indexes before modeling,after modeling and post-treatment respectively.Results Abnormal changes in behavior were observed following modeling among these rats,with significantly increased WBC number in peripheral blood and acute inflammatory figure in the histopathology of nasopharyngeal mucosa further.In contrast,significantly improved indexes were seen among the animals treated by FITDB,when compared with that of modeling rats(P<0.05),and it showed similar therapeutic effect as that of ampicillin on PCG(P>0.05).Conclusions FITDB holds significant therapeutic effect on experimental acute nasopharyngitis of rats.