Effect modification of air pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions |
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| Authors: | Cizao Ren Pantel S Vokonas Helen Suh Shona Fang David C Christiani Joel Schwartz |
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| Affiliation: | 1.Exposure, Epidemiology, and Risk Program, Department of Environmental Health,Harvard School of Public Health,Boston,USA;2.VA Normative Aging Study, Veterans Affairs Boston Healthcare System and the Department of Medicine,Boston University School of Medicine,Boston,USA;3.Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health,Harvard School of Public Health,Boston,USA |
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| Abstract: | Background Air pollution is associated with adverse human health, but mechanisms through which pollution exerts effects remain to be clarified. One suggested pathway is that pollution causes oxidative stress. If so, oxidative stress-related genotypes may modify the oxidative response defenses to pollution exposure. |
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