东北南星不同炮制品的毒性及刺激性研究

目的：考查不同炮制方法（浸、煮）及不同辅料（矾、姜、胆汁）对东北南星毒副作用的影响。方法：通过口尝麻辣味、兔眼刺激、急性毒性实验，考查东北南星及其不同炮制品的刺激性及毒性。结果：口尝麻醉味实验结果表明，矾制比姜制去麻效果好，加热比不加热去麻效果好；兔眼刺激实验结果与口尝麻辣味实验结果具平行性；急性毒性实验表明东北南星生品混悬液毒性不明显。结论：实验说明，现行天南星炮制方法多采用白矾为辅料，加热炮制天南星，具有科学依据。东北南星生品临床使用具有一定安全性。

Study on Toxicity and Adverse Effect of Different Processed Samples of Arisaema Amurense Maxim

Objective: To investigate the effects of different processing methods (steeping, boiling) and different adjuvants (alum, ginger, bile) on toxicity and adverse effect of Arisaema Amurense Maxim. Methods: The determinations of toxicity and adverse effect were performed by tasting of hot and tingle, test of stimulating rabbit eyes and acute toxicity test. Results: The product processed by alum is better than that by ginger in eliminating hot and tingle taste. The product processed by heating is better than that without heating. The test result of stimulating rabbit eyes is similar to that of hot and tingle taste. The result of acute toxicity test indicates that the toxicity of Arisaema Amurense Maxim is low. Conclusions: It is scientific that Arisaema Amurense Maxim. is mostly processed by alum and heat. The clinical application of Arisaema Amurense Maxim. has a certain safety.