腹膜透析患者血清白蛋白水平影响因素分析

目的通过对持续性非卧床腹膜透析(CAPD)患者的研究,探讨影响患者血清白蛋白(Alb)水平的可能因素。方法选择北京大学第一医院腹膜透析中心217例患者,按照其血清白蛋白水平分为两组:Alb≤35g/L组和Alb>35g/L组,分析血清白蛋白与其它营养指标之间的关系及其影响因素。结果血清白蛋白水平与握力、血肌酐显著相关,营养不良的患者血清白蛋白显著降低。多因素回归分析发现血清C-反应蛋白、容量状态、合并症、年龄对血清白蛋白水平有显著影响(P<0.05)。结论本研究发现血清白蛋白水平与营养指标密切相关,但除营养指标之外的一些因素也可显著影响血清白蛋白水平,这包括炎症、体内液体容量负荷过多、合并症等等。因此,在将血清白蛋白作为评估患者营养状态时应注意排除这些因素的影响。

Factors influencing serum albumin in peritoneal dialysis patients

Objective To analyze the factors influencing serum albumin in peritoneal dialysis patients.Methods 217 continuous ambulatory peritoneal dialysis patients were enrolled.The patients were divided into tow groups according to their serum albumin levels.The relationship between serum albumin and other parameters were analyzed using stepwise multivari-ate regression analysis.Results Serum albumin was positively correlated with hand-grip strength and serum creatinine.Serum albumin was significant lower in malnourished patients.Regression analysis showed that complication,fluid status,age,SCRP were significant independent predic-tors of serum albumin(P <0.05).Conclusion Serum albumin level could be uses in nutritional assessment.However,serum albumin level was influenced by multiple factors,including inflammation,fluid status,complication and age which should thus be taken into account when using albumin as a nutritional parameter.