血清抗环瓜氨酸肽抗体在类风湿关节炎诊断中的评价

目的:评价抗环瓜氨酸抗体在类风湿关节炎(RA)诊断中的价值。方法:用ELISA法检测RA及疑似患者血清中的抗环瓜氨酸肽(CCP)抗体。比较抗CCP抗体和类风湿因子(RF)对RA诊断的敏感度、特异度及诊断预测性方面的差异。结果:抗CCP抗体的敏感度为42.5%,RF为67.8%,RF高于抗CCP抗体(P<0.05),抗CCP抗体的特异度为97.4%,RF为78.7%,抗CCP抗体明显高于RF(P<0.05),在RA诊断预测中,抗CCP抗体明显优于RF(P<0.05)。结论:抗CCP抗体在RA诊断中具有高的特异性和预测性,可作为诊断RA的理想血清学指标。

Value of anti-cyclic citrullinated peptide antibody in the diagnosis of rheumatoid arthritis

Objective To explore the value of anti-cyclic citrullinated peptide (CCP) antibody in the diagnosis of rheumatoid arthritis (RA). Methods Serum anti-CCP was detected by enzyme linked immunosorbent assay in 151 patients. The sensitivity, specificity and predictability to RA of anti-CCP were compared with those of rheumatoid factor (RF). Results The sensitivity of anti-CCP and RF was 42.5% and 67.8% respectively. The sensitivity of RF was higher than that of anti-CCP (P<0.05). The specificity of anti-CCP and RF was 97.4% and 78.7% respectively. The specificity of anti-CCP was higher than that of RF (P<0.05). The predictability to RA of anti-CCP was higher than that of RF (P<0.05). Conclusions Anti-cyclic citrullinated peptide antibody has high specificity and predictability, which might be used as a valuable parameter in the diagnosis of RA.