| 三硝基甲苯（TNT）对大鼠形态与生化致畸作用的研究 |
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| 引用本文： | 刘凤巧 江泉观. 三硝基甲苯（TNT）对大鼠形态与生化致畸作用的研究[J]. 工业卫生与职业病, 1989, 15(3): 131-133 |
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| 作者姓名： | 刘凤巧 江泉观 |
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| 作者单位： | 北京医科大学(刘凤巧)，北京医科大学(江泉观) |
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| 基金项目： | 卫生部七、五攻关项目,课题编号:75-62-03-29-05 |
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| 摘 要： | 孕鼠在怀孕第6—15天,每日一次灌胃给药,于第20天处死,TNT1/10LD_(50)和1/80LD_(50)两剂量组胚胎毒性表现为胎鼠骨骼系统畸形,并有皮下出血;胎鼠肝脏还原型谷胱甘肽(GSH)含量均显著下降,肝氧化型谷胱甘肽(GSSG)含量皆上升;但肝糖元含量无明显变化。
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| 关 键 词： | 三硝基甲苯 胚胎毒性 致畸作用 |
THE MORPHOLOGICAL AND BIOCHEMICAL TERATOGENIC EFFECTS OF TRINITROTOLUENE (TNT) IN RATS |
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| Liu Fengqiao et al. THE MORPHOLOGICAL AND BIOCHEMICAL TERATOGENIC EFFECTS OF TRINITROTOLUENE (TNT) IN RATS[J]. Industrial Health and Occupational Diseases, 1989, 15(3): 131-133 |
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| Authors: | Liu Fengqiao et al |
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| Affiliation: | The Beijing Medical University |
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| Abstract: | The morphological and biochemical teratogenic actions in rats were investigated. Peroral administration of 1/10 and 1/80 LD50 doses of TNT to Wistar rats, from the 6th through 15th day of gestation, elicited fetal anomalies. Most abnormalities were observed in the skeletal system, and the embryo toxicity appeared as subcutaneous haemorrhage. The GSH content was decreased and GSSG content was increased in fetal liver given 1/10 and 1/80 LD50 doses,but the glycogen content had no significant changes. |
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| Keywords: | trinitrotoluene(TNT) embryo toxicity teratogenic action |
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