Effect of volume of porogens on the porosity of PLGA scaffolds in pH-controlled environment |
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| Authors: | Manish Gupta Adeyinka Aina Yamina Boukari Stephen Doughty Andrew Morris Nashiru Billa |
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| Affiliation: | 1. Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Semenyih, Malaysia;2. School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia;3. Pharmaceutical Manufacturing Technology Centre, University of Limerick, Limerick, Ireland;4. Penang Medical College, George Town, Malaysia |
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| Abstract: | Poly(lactic-co-glycolic acid) (PLGA) is a well-studied biodegradable polymer used in drug delivery and other medical applications such as in tissue regeneration. It is often necessary to impart porosity within the scaffold (microparticles) in order to promote the growth of tissue during the regeneration process. Sodium chloride and ammonium bicarbonate have been extensively used as porogens in the generation of porous microstructure. In this study, we compared the effect of volumes (250?μl, 500?μl and 750?μl) of two porogens, sodium chloride (1.71 M) and ammonium bicarbonate (1.71 M), on the porosity of PLGA microparticles. |
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| Keywords: | Porosity PLGA scaffolds tissue regeneration and porogens |
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