非离子表面活性剂囊泡作为阿司匹林药物载体的研究

目的研究非离子表面活性剂囊泡对阿司匹林的包封率及其释放行为的影响，为新型药物传输系统的研究提供一定的依据。方法以Span-60和胆固醇为主要原料，通过真空旋转一超声波法制备了非离子表面活性剂囊泡，研究了该类囊泡对阿司匹林的包封作用以及被包封的阿司匹林在模拟胃液及模拟肠液中的释放情况。结果0．01mol／L司盘60：胆固醇：1：1时形成的非离子表面活性剂囊泡对0．2mg／ml的阿司匹林的包封率是91％；药物释放实验显示，在模拟胃液和模拟肠液中游离阿司匹林的释放率为98％，包封于囊泡中的阿司匹林的释放率为50％。结论非离子表面活性剂囊泡对阿斯匹林具有较高的包封率及明显缓释作用。

Studies on niosomes as durg carrier of Aspirin

Objective To investigate the entrapment efficiency and the release rate of Aspirin encapsulated into noiosomes,and provide the guidance for the study of the new drug delivery system. Methods Niosomes were prepared with nonion surfactant span-60 and cholesterol by ultrasonication. And the entrapment efficiency of Aspirin encapsulated into noiosomes and release profiles in simulated gastric and intestinal fluid were studied. Results The results showed that the entrapment efficiency of aspirin by noiosomes reached 91% under the condition that the molar ratio of the span-60：cholesterol equaled to 1 ： 1 and the concentration of aspirin was 0.2mg/mL. The resuits also indicated that in simulated gastric and intestinal fluid, the release rate of Aspirin entrapped in niosomes was 50% after 3h,however the release rate of free Aspirin was 98% under the same condition. Conclusion The entrapment efficiency of Aspirin entrapped by niosomes was high enough and the release rate of the entrapped drug was slow obviously.