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| 螺内酯杂质的分离与结构鉴定 | |
| 引用本文： | 赵莲,陈华,王友富,李援朝.螺内酯杂质的分离与结构鉴定[J].中国药学杂志,2008,43(3):230-231. |
| 作者姓名： | 赵莲 陈华 王友富 李援朝 |
| 作者单位： | 1. 河北大学化学与环境科学学院,河北保定,071002 2. 浙江仙居制药二分厂,浙江,仙居,317300 3. 中国科学院上海生命科学院药物研究所,上海,201203 |
| 摘 要： | 目的研究药物螺内酯中所含的杂质。方法应用色谱方法进行分离和纯化,NMR和MS等波谱解析化学结构。结果从螺内酯母液中分离得到2个化合物,分别鉴定为7α-乙酰硫基-17β-甲氧基-孕甾-4-烯-3-酮(2)和17β-羟基-3-氧代孕烷-4-烯-21-羧酸-γ-内酯(3)。结论化合物2为新化合物。 |
| 关 键 词： | 螺内酯 7α-乙酰硫基-17β-甲氧基-孕甾-4-烯-3-酮 |
| 文章编号： | 1001-2494（2008）03-0230-03 |
| 收稿时间： | 2006-04-13 |
| 修稿时间： | 2006年4月13日 |
Isolation and Identification of Impurities in Spironolactone |
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| ZHAO Lian,CHEN Hua,WANG You-fu,LI Yuan-chao.Isolation and Identification of Impurities in Spironolactone[J].Chinese Pharmaceutical Journal,2008,43(3):230-231. | |
| Authors: | ZHAO Lian CHEN Hua WANG You-fu LI Yuan-chao |
| Institution: | 1.College of Chemistry and Environment Sciences,HeBei University,Baoding 071002,China; 2. Zhejiang Xianju Second Pharmaceutic Factory,Xianju 317300,China;3. Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 201203,China |
| Abstract: | OBJECTIVE To study the impurity of spironolactone.METHODS The chemical constituents were separated by chromatography.The structure was determined by NMR and MS spectral analysis.RESULTS Two spironalactone-analogs were isolated and identified as 7α-acetylthio-17β-methoxy-pregn-4-en-3-one(2) and 17β-hydroxy-3-oxopregna-4-ene-21-carboxylic acid γ-lactone(3).CONCLUSION Compound 2 was a new compound. |
| Keywords: | spironolactone 7α-acetylthio-17β-methoxy-pregn-4-en-3-one" target="_blank">α-acetylthio-17β-methoxy-pregn-4-en-3-one ')" href="#"> 7α-acetylthio-17β-methoxy-pregn-4-en-3-one |
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