Iron overload in patients with myelodysplastic syndromes |
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Authors: | Peter-D Jensen MD PhD DMSci |
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Institution: | 1. Department of Hematology, ?rhus University Hospital, Aalborg Hospital, Hobrovej 42A, DK-9100, Aalborg, Denmark
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Abstract: | The myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell diseases characterized by ineffective hematopoiesis
in one or more cell lines, resulting in insufficient bone marrow function. For most patients with MDS, supportive care by
blood transfusions is still the mainstay of treatment. Especially in low-risk patients, anemia represents the major clinical
problem, and many of these patients develop transfusional iron overload. This paper reviews the literature on transfusional
iron overload in patients with MDS, looking at pathophysiology, evaluation, and treatment of the transfusional iron burden
with desferrioxamine and oral chelators. |
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Keywords: | |
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