In vivo measurement of plaque burden in a mouse model of Alzheimer's disease |
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| Authors: | Borthakur Arijitt Gur Tamar Wheaton Andrew J Corbo Matthew Trojanowski John Q Lee Virginia M-Y Reddy Ravinder |
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| Institution: | Metabolic Magnetic Resonance Research & Computing Center (MMRRCC), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6100, USA. ari@mail.mmrrcc.upenn.edu |
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| Abstract: | PURPOSE: To demonstrate an MRI method for directly visualizing amyloid-beta (Abeta) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T1rho relaxation rate increases progressively with Alzheimer's disease (AD)-related pathology in the tg mouse brain. MATERIALS AND METHODS: We obtained in vivo MR images of a mouse model of AD (APP/PS1) that overexpresses human amyloid precursor protein, and measured T1rho via quantitative relaxometric maps. RESULTS: A significant decrease in T1rho was observed in the cortex and hippocampus of 12- and 18-month-old animals compared to their age-matched controls. There was also a correlation between changes in T1rho and the age of the animals. CONCLUSION: T1rho relaxometry may be a sensitive method for noninvasively determining AD-related pathology in APP/PS1 mice. |
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| Keywords: | Alzheimer's disease amyloid‐β T1rho spin‐lock imaging MRI |
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