急性冠脉综合征与血清胆红素水平的相关性分析

目的探讨急性冠脉综合征与血清胆红素水平的相关性.方法采集空腹静脉血检测76例急性冠脉综合征患者及38例对照组的血清胆红素和血脂水平.将急性冠脉综合征患者分为不稳定型心绞痛组和急性心肌梗死组,与对照组比较血清胆红素水平的差异,并进行血清胆红素与血脂Pearson直线相关分析.结果不稳定型心绞痛组和急性心肌梗死组血清总胆红素和直接胆红素水平均明显低于对照组,差异有统计学意义(P＜0.01).不稳定型心绞痛组和急性心肌梗死组之间血清总胆红素和直接胆红素水平差异无统计学意义(P＞0.05).血清总胆红素和直接胆红素与总胆固醇、三酰甘油、低密度脂蛋白均呈负相关(P＜0.05);与高密度脂蛋白呈正相关(P＜0.05).结论血清胆红素水平降低可能是急性冠脉综合征发生和发展的危险因素.

Correlation analysis of acute coronary syndrome and serum bilirubin level

Objective To investigate the correlation between acute coronary syndrome and serum bilirubin level.Methods The fast vein blood was gathered to examine the serum bilirubin and serum lipid levels of in 76 cases of acute coronary syndrome and 38 controls.The patients with acute coronary syndrome were divided into unstable angina and acute myocardial infarction group.The difference of serum bilirubin level was compared with control group.Pearson linear correlation analysis was carried out in serum bilirubin and serum lipid.Results The serum total bilirubin and direct bilirubin were clearly lower in unstable angina pectoris group and acute myocardial infarction group than control group(P<0.01).There was no statistic difference in serum total bilirubin and direct bilirubin between unstable angina and acute myocardial infarction group(P>0.05).The serum total bilirubin and direct bilirubin were negatively correlated with total cholesterol,triglyceride,and low-density lipoprotein(P<0.05),but positively correlated with high-density lipoprotein(P<0.05).Conclusion The reduction of serum bilirubin level may be the risk factors of acute coronary syndrome occurrence and development.