| 应激相关的热休克信号转导通路的研究进展 |
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| 引用本文： | 李煜生,姜勇. 应激相关的热休克信号转导通路的研究进展[J]. 中国病理生理杂志, 2005, 21(5): 1030-1035. DOI: 1000-4718 |
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| 作者姓名： | 李煜生 姜勇 |
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| 作者单位： | 南方医科大学病理生理学教研室和广东省功能蛋白质组学重点实验室， 广东 广州 510515 |
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| 基金项目： | 国家杰出青年科学基金资助项目(No.39925014)，国家自然科学基金资助项目(No.30030060)，重大基础理论研究(973)计划项目(No.2002CB513000)，国家高技术研究发展计划(863)课题(No.2001AA234061) |
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| 摘 要： | 随着社会的发展和医疗技术的不断进步与完善,人们的健康水平有了大幅度的提高。但急性梗塞(如脑梗、心梗)、感染性疾病(如败血症)等仍有较高的发病率和死亡率。特别是随着我国社会和经济的发展,老年人群的结构比例明显增高,心脑血管疾病和感染引起的疾病将进一步增加。而且随着
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| 关 键 词： | 热休克因子 热休克元件 热休克蛋白质类 信号转导 |
| 文章编号： | 1000-4718(2005)05-1030-06 |
| 收稿时间： | 2003-12-15 |
| 修稿时间： | 2004-02-09 |
Progress in stress-induced heat shock signaling pathways |
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| LI Yu-sheng,JIANG Yong. Progress in stress-induced heat shock signaling pathways[J]. Chinese Journal of Pathophysiology, 2005, 21(5): 1030-1035. DOI: 1000-4718 |
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| Authors: | LI Yu-sheng JIANG Yong |
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| Affiliation: | Department of Pathophysiology and Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University, Guangzhou 510515, China |
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| Abstract: | A lot of diseases (e.g., acute infarction and infections) and the diversity of harmful environmental changes, including elevating temperature, heavy metals and oxidants damage many kinds of proteins in organism. The denatured proteins usually evoke endogenous adaptive cellular mechanisms called heat shock response. After the activation, heat shock factors (HSFs) bind with heat shock element (HSE). This progress induces heat shock protein (HSP) expression, then facilitates repair of misfolded proteins, and finally inhibits the cell death (both necrosis and apoptosis) pathways. This review will introduce the structures and functions of HSF, HSP and HSE and details on the signaling process of HSP regulation by HSF. |
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| Keywords: | Heat shock factor Heat shock element Heat shock proteins Signal transduction |
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