Effects of muscarine agonists and antagonists on vasopressin-stimulated water transport in the amphibian bladder |
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| Authors: | Ya Yu Bagrov N I Dmitrieva N B Manusova |
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| Institution: | (1) Laboratory for Comparative Physiology and Biochemistry of Tissue Barriers, I. M. Sechenov Institute of Evolutional Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg |
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| Abstract: | The effects of M1 and M2 cholinoceptors on stimulated water transport in the urinary bladder of the common frogRana temporaria L. are described. In the presence of pirenzepine, a selective M1 cholinoceptor antagonist, carbachol stimulated water transport. Activation of M2 cholinoceptors by oxotremorine in concentrations of 0.5–5.0 μM inhibited water transport, whereas their activation by this
compound in higher concentrations (10–100 μM) stimulated it. The use of the phospholipase C inhibitor neomycin (0.5 mM) and
the calmodulin inhibitor W-7 (1 mM) indicated that activation of M2 cholinoceptors switches on phospholipid-Ca2+-calmodulin-dependent mechanisms.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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9, pp. 252–254, September, 1995
(Presented by P. V. Sergeev, Member of the Russian Academy of Medical Sciences) |
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| Keywords: | amphibian bladder Arginine vasopressin M 1 and M2 cholinoceptors oxotremorine |
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