辛伐他汀对高脂血症患者载脂蛋白E的影响

目的探讨辛伐他汀对高脂血症患者血清总载脂蛋白E(apoE)水平的影响。方法40例高脂血症患者每晚顿服辛伐他汀10mg4周，比较服药前后血清甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、apoA1、apoB、apoE及脂蛋白(a)〔Lp(a)〕水平的变化。结果用药后血清TC及TG分别下降21．3％及9．2％(P<0．001，<0．05)，LDL-C下降24．7％(P<0．01)，apoB及apoE分别下降13．8％及34．7％(P<0．05，<0．001)，apoA1增加7．5％(P<0．05)。apoE下降幅值分别与其自身基础值和TG及LDL-C基础值呈正相关(P<0．01，<0．01，<0．05)。HDL-C呈增高趋势，Lp(a)改变无统计学差异。结论辛伐他汀能导致血清apoE水平显著下降其可能参与了抗动脉粥样硬化过程。

Influence of simvastatin on apolipoprotein E in patients with hyperlipemia

Objective: To study the influence of simvastatin on apolipoprotein E in patients with hyperlipemia. Method:40 patients with hyperlipemia were taken simvastatin 10 mg/d qn,PO. Blood samples were taken from forearm vein before and 4 weeks after the treatment. Their serum total cholesterol (TC) ,triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (apoA1),apolipoprotein B (apoB),apolipoprotein E (apoE) and lipoprotein (a) were measured and compared. Result:Simvastatin decreased serum TC levels and TG levels by 21.3% and 9.2% ( P ＜0. 001 ,＜0. 05),decreasing serum LDL-C levels,apoB levels and apoE levels by 24.7% ,13.8% and 34.7% ( P ＜0.01 ,＜0.05,＜0.001). The concentrations of serum HDL-C were risen by 7.5% (P ＜0.05). Serum apoA levels displayed an increasing tendency. The value of Lp(a) was not significant difference after treatment. Amplitude of lowering apoE showed positive correlation with base value of apoE,TG and LDL-C ( P ＜0. 01 ,＜0.01 ;＜0.05). Conclusion:Simvastatin could lead to markedly decrease serum apoE concentrations in patient with hyperlipemia, which might take part in the course of resisting therosclerosis.