小儿慢性荨麻疹与肺炎支原体感染的相关性研究

目的探讨小儿慢性荨麻疹与肺炎支原体感染的关系及其可能的发病机制。方法选取66例3～13岁不明原因的慢性荨麻疹患儿作为实验组。选取60例同期住院非过敏性疾病的3～13岁患儿作为对照组，采用特异性免疫凝集试验检测所有儿童外周血清MP—IgM抗体，同时对血清嗜酸性粒细胞、总IgE值进行检测。结果实验组MP感染率高于对照组，差异具有高度统计学意义（X。=9．68，P〈0．01）；实验组血清嗜酸性粒细胞显著高于对照组，差异有高度统计学意义（f=6．35，P〈0．01）；实验组总IgE值显著高于对照组，差异有高度统计学意义（t=5．53，P〈0．01）；EOS计数与IgE表达呈正相关（r=0．76，P〈0．01）。结论MP感染与小儿慢性荨麻疹存在因果关系，对小儿慢性荨麻疹律议常规榆测MP抗体：MP感染引起慢件荨麻疹可能与由IgE介导的Ⅰ型变态反应有关．

Discussion on the relationship between mycoplasma pneumoniae infeetion and chronic urticaria in children

Objective To explore the relationship between myeoplasma pneumoniae infeetion and chronic urticaria in children,and to analyze the possible pathogenesis.Methods All 66 cases were selected from 3 to 13 years old unexplained chronic urticaria children for the test group,and 60 patients in hospital at the same period of no allergic disease were selected from 3 to 13 years old as control group,age and sex was not statistically different between two groups.All children peripheral blood serum MP-IgM antibodies detected by the specific immune agglutinate test,and test the serum eosinophi land total IgE.Results The MP infection rates in test group was higher than those in the control group(χ2= 9.68,P < 0.01),there was a statistically significant difference.The serum eosinophil in test group was significantly higher than those in the control group,there was statistically significant difference(t = 6.35,P < 0.01).The total IgE value in test group was significantly higher than those in the control group,there was statistically significant difference(t = 5.53,P < 0.01);EOS count and IgE expression were positively correlated.Conclusion MP infection and pediatric chronic urticaria exist causality,for children chronic urticaria suggest inspecting MP antibody conventionally.MP infection is related to the pathogenesis of chronic urticaria may be mediatedⅠ type allergy relevant by the IgE.