MMP-9在胰腺癌组织中的表达及意义

目的探讨MMP-9在胰腺癌组织中的表达及其与临床病理因素的关系。方法采用免疫组织化学技术检测73例胰腺癌、37例胰腺正常组织中MMP-9蛋白的表达，并对其与临床病理因素的关系进行相关性分析。结果胰腺癌与正常胰腺组织MMP-9蛋白表达阳性率差异有统计学意义，分别为65．75％和10．81％（P〈0．05）。胰腺癌组中，中高分化病例MMP-9蛋白表达阳性率为45．45％，低分化病例为74．51％，二者比较，差异有统计学意义（P〈0．05）；A＋B期病例MMP-9蛋白表达阳性率为43．59％，明显低于C＋D期（91．18％）（P〈0．05）；≤60岁病例MMP-9蛋白表达阳性率为59．52％，〉60岁病例阳性率为74．19％，二者比较差异无统计学意义（P〉0．05）。结论MMP-9蛋白的表达在胰腺癌组织中明显增高，且与其组织分化、临床分期有关，与患者年龄大小无关。MMP-9蛋白表达与胰腺癌的发生发展密切相关，在胰腺癌的诊断方面可能是比较好的协助诊断分型、判断预后因子。

The expression and clinical significance of MMP-9 in pancreatic cancer

Objective To investigate the expression of MMP-9 in pancreatic cancer,and to explore its relations with clinicopathological factors.Methods Immunohistochemistry was used to detect the expression of MMP-9 in 73 cases of pancreatic cancer,and 37 cases of normal pancreas.Results The positive rate of MMP-9 had significant difference between patients with pancreatic cancer and normal pancreas(P < 0.05).The expression of MMP-9 was correlated with grade and stage of pancreatic cancer(P < 0.05),but not to age of onset(P > 0.05).Conclusion The expression of MMP-9 may play a role in the tumorigenesis and progression of pancreatic cancer.MMP-9 could be a factor to diagnose the typing of pancreatic cancer and predict the prognosis of pancreatic cancer.