Impact of plasma and intracellular exposure and CYP3A4, CYP3A5, and ABCB1 genetic polymorphisms on vincristine-induced neurotoxicity |
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| Authors: | Guilhaumou Romain Solas Caroline Bourgarel-Rey Veronique Quaranta Sylvie Rome Angelique Simon Nicolas Lacarelle Bruno Andre Nicolas |
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| Affiliation: | (1) Aix-Marseille Univ, CRO2, INSERM, UMR 911, 13385 Marseille, France;(2) Laboratoire de Pharmacocin?tique et Toxicologie, H?pital de la Timone, 264 rue Saint Pierre, 13385 Marseille Cedex 5, France;(3) Service d’Oncologie P?diatrique, H?pital de la Timone, 264 rue Saint Pierre, 13385 Marseille Cedex 5, France;(4) Laboratoire de Pharmacologie M?dicale et Clinique, H?pital de la Timone, 264 rue Saint Pierre, 13385 Marseille Cedex 5, France |
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| Abstract: | Purpose The aim of this study was to investigate the impact of plasma and intracellular exposure and CYP3A4, CYP3A5, and ABCB1 polymorphisms on vincristine neurotoxicity. We subsequently assessed the impact of ABCB1 polymorphisms on intracellular vincristine accumulation. |
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