Evening melatonin and bright light administration induce additive phase shifts in dim light melatonin onset |
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Authors: | Wirz-Justice Anna Kräuchi Kurt Cajochen Christian Danilenko Konstantin V Renz Claudia Weber Jakob M |
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Affiliation: | Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland. anna.wirz-justice@unibas.ch |
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Abstract: | In healthy young men, administration of a single light pulse (5000 lux for 3 hr) or a single melatonin pill (5 mg) at 20:40 hr under controlled constant routine conditions of <10 lux, yielded a phase delay and a phase advance, respectively, in the circadian marker of dim light melatonin onset 24 hr later. Phase shifts after combining the two interventions were additive. Melatonin suppression is not necessary for a phase shift by light, and melatonin is not a 'weak' Zeitgeber relative to bright light when ambient lighting is strictly controlled. |
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Keywords: | bright light dim light melatonin onset human circadian rhythms melatonin Zeitgeber |
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